• br Materials and Methods br Acknowledgements Authors

  2021-05-20

  

  Materials and Methods Acknowledgements Authors would like to thank Mr. Pritam Naskar and Mr. Dibya Mukherjee for their help. Authors also acknowledge the help of Mr. Barun Mahata and Dr. Kaushik Biswas, Division of Molecular Medicine, Bose Institute, for human cDNA samples. P.A.B. and A.B.D. w

• Dysfunction of the ubiquitin proteasome system causes abnorm

  2021-05-20

  

  Dysfunction of the ubiquitin-proteasome system causes abnormal organelle morphology and impairs sperm formation and maturation steps resulting in male infertility [[7], [8], [9]]; this indicates that ubiquitination is essential for spermatogenesis and sperm function during fertilization. β-catenin i

• In a study carried out

  2021-05-20

  

  In a study carried out by Aunis et al. the properties of soluble DBH and membrane bound were examined [23]. The membrane bound enzyme was shown in alk inhibitor to the soluble form to have thermal denaturation at higher temperatures of 43.5–44°C. Similar discontinuities in the Arrhenius plots were

• Herein the interactions of etamicastat nepicastat and

  2021-05-20

  

  Herein, the interactions of etamicastat, nepicastat and zamicastat with P-gp and BCRP were evaluated. Although recent investigations have been performed to assess the involvement of P-gp in the Ferrostatin-1 exposure of nepicastat and etamicastat (Loureiro et al., 2015), the contribution of BCRP re

• Mother rats acutely treated with quinpirole and

  2021-05-20

  

  Mother rats acutely treated with quinpirole (0.5 and 1.0 mg/kg) decreased the pup exploration time but increased the object exploration, so they showed a significantly lower pup preference ratio. They also showed impaired maternal performance in the home cage, consistent with our previous study (Zha

• Present malarial chemotherapies mainly rely on a very few ch

  2021-05-20

  

  Present malarial chemotherapies mainly rely on a very few chemotypes or their allied structures such as quinolines, anti-folates and some cyclic endo-peroxides (Nayyar et al., 2012). Over the last few decades, the extensive and repetitive deployment of these drugs has stimulated resistance in the pa

• br Cyclin dependent kinases control

  2021-05-19

  

  Cyclin-dependent kinases control more than cell cycle CDKs’ roles conducting the concert of Tioconazole was first revealed in the context of the tumor suppressor Rb, phosphorylation of which by CDK4 or CDK6 inactivates it loosing the transcription factor E2F [1], [12], [15]. Discovery of other c

• br Materials and methods br Results br Discussion

  2021-05-19

  

  Materials and methods Results Discussion CDK and their regulatory cyclins form a family of heterodimeric kinases that are particularly important for regulation of diltiazem hcl progression and transcription in tumor cells. These kinases therefore constitute biomarkers of proliferation and

• Among the other mediators which have

  2021-05-19

  

  Among the other mediators which have been reported to play a role in erection are prostaglandins (PGs). Several studies have reported that alprostadil- synthetic PGE1- showed high efficacy in management of erectile dysfunction as it induces corpus cavernosal relaxation. Alprostadil has been first de

• Introduction Safety critical systems are defined as those sy

  2021-05-19

  

  Introduction Safety-critical systems are defined as those systems where failure could result in the loss of life or injury to people, damage to equipment or to the environment [9]. Safety standards, e.g., [41], [17], [18], [6], [38], expect appropriate safety analysis tasks to be integrated within

• br Methods br Results br Discussion Literature showed SN was

  2021-05-19

  

  Methods Results Discussion Literature showed SN was well studied for its antigastric ulcer, antiinflammatory, antihyperglycemic, and antihyperlipidemic properties. Although a recent publication reported that SN was found to exert its regulatory effect in animal cholesterol levels, the exact

• Cell swelling stimulates the release of

  2021-05-19

  

  Cell swelling stimulates the release of certain amino acids, in particular the non-protein amino Cilnidipine synthesis taurine, via a pathway which has the characteristics of a channel rather than a carrier [54], [69]. Indeed, on the basis of pharmacological inhibition, it was suggested that volume

• The modes of action of insecticides are

  2021-05-19

  

  The modes of action of insecticides are classified by the Insecticide Resistance Action Committee (IRAC) [6]. In this classification, a large proportion of insecticides are categorized as nerve- and muscle-targeting insecticides, which encompass GABACl antagonists (Group 2) and GluCl allosteric modu

• br Experimental Procedures br Author Contributions M M and M

  2021-05-19

  

  Experimental Procedures Author Contributions M.M. and M.T. designed and supervised the study. S.I. conducted the analysis on NOG-rd mice. H.-Y.T., M.F., and T.M. conducted and analyzed MEA. S.I., H.-Y.T., and M.M. performed 3D image analysis. N.K., T.K., M.G., and R.T. planned and established

• Introduction Penetrator with Enhanced Lateral

  2021-05-19

  

  Introduction Penetrator with Enhanced Lateral Effect (PELE) is a kind of ammunition which consists of a low-density material as the filling and a high-density material as the jacket [1,2]. When PELE impact target, the jacket is radially accelerated, expanded and fractured because of distinctive lat

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